Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 252 | 66 | 181 |
| Samples | 161 | 50 | 108 |
| Peptides | 124 | 35 | 94 |
Function
TNFSF8 · TNF superfamily member 8
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000223795 | P32971 | 164 | 115 |
| ENST00000618336 | A0A087X228* | 88 | 70 |
Gene Properties
Recurrent Mutations
All 115 amino-acid changes on canonical ENST00000223795 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TNFSF8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TNFSF8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Glioblastoma | 2/98 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Melanoma | 5/210 2% | 22/1899 1% |
| Endometrial Carcinoma | 2/42 5% | 6/612 1% |
| Colorectal Carcinoma | 6/143 4% | 20/3239 1% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Other Sarcomas | 3/69 4% | 1/699 0% |
| Other Solid Cancers | 2/94 2% | 6/1515 0% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Ovarian Carcinoma | 4/109 4% | 1/998 0% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Gastric Carcinoma | 3/74 4% | 5/1809 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 2/2534 0% |
| Kidney Carcinoma | 2/85 2% | 3/1862 0% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 2/1390 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 2/810 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Biliary Tract Carcinoma | 0/54 0% | 2/950 0% |
| Prostate Carcinoma | 1/13 8% | 3/2105 0% |
| Breast Carcinoma | 2/144 1% | 4/3264 0% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 1/2550 0% |
| Neuroblastoma | 2/87 2% | 0/1331 0% |
| Esophageal Carcinoma | 1/23 4% | 0/769 0% |
| Hepatocellular Carcinoma | 0/46 0% | 3/2210 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
Mutation Distribution
Where TNFSF8 is mutated · all tissues, split by cell line vs tissue
How many mutations in TNFSF8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 252 mutations in TNFSF8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|