Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,654 | 257 | 1,359 |
| Samples | 591 | 136 | 442 |
| Peptides | 479 | 88 | 394 |
Function
TNK2 · Tyrosine kinase non receptor 2
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
7 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000381916 | A0A499FJ16* | 531 | 400 |
| ENST00000333602 | Q07912 | 514 | 387 |
| ENST00000428187 | C9J1X3* | 512 | 383 |
| ENST00000672887 | A0A5F9ZGX5* | 92 | 63 |
| ENST00000673038 | A0A5F9ZHJ2* | 2 | 2 |
| ENST00000673420 | A0A5F9ZI29* | 2 | 2 |
| ENST00000672548 | A0A5F9ZHD0* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 387 amino-acid changes on canonical ENST00000333602 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TNK2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TNK2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Chordoma | 1/7 14% | 1/13 8% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 8/42 19% | 21/612 3% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Burkitts Lymphoma | 1/32 3% | 6/196 3% |
| Colorectal Carcinoma | 24/143 17% | 75/3239 2% |
| Melanoma | 11/210 5% | 45/1899 2% |
| Non-Small Cell Lung Carcinoma | 19/304 6% | 26/1390 2% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 15/810 2% |
| Gastric Carcinoma | 5/74 7% | 36/1809 2% |
| Other Solid Cancers | 3/94 3% | 29/1515 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Germ Cell Tumour | 1/25 4% | 2/169 1% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Thyroid Gland Carcinoma | 3/45 7% | 20/1592 1% |
| Neuroendocrine Tumour | 4/154 3% | 6/577 1% |
| Chondrosarcoma | 1/14 7% | 0/75 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Head and Neck Carcinoma | 5/85 6% | 13/1574 1% |
| Ovarian Carcinoma | 4/109 4% | 7/998 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 25/2550 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Other Sarcomas | 2/69 3% | 5/699 1% |
| Biliary Tract Carcinoma | 1/54 2% | 8/950 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Glioma | 1/52 2% | 18/2127 1% |
| Hepatocellular Carcinoma | 1/46 2% | 17/2210 1% |
Mutation Distribution
Where TNK2 is mutated · all tissues, split by cell line vs tissue
How many mutations in TNK2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,654 mutations in TNK2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|