Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 309 | 38 | 268 |
| Samples | 127 | 19 | 106 |
| Peptides | 102 | 14 | 86 |
Function
TP53I3 · Tumor protein p53 inducible protein 3
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 83 amino-acid changes on canonical ENST00000238721 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TP53I3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TP53I3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Burkitts Lymphoma | 3/32 9% | 1/196 1% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Melanoma | 2/210 1% | 13/1899 1% |
| Other Solid Cancers | 0/94 0% | 8/1515 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 3/1390 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Colorectal Carcinoma | 0/143 0% | 10/3239 0% |
| Hepatocellular Carcinoma | 0/46 0% | 5/2210 0% |
| Neuroblastoma | 3/87 3% | 0/1331 0% |
| Biliary Tract Carcinoma | 0/54 0% | 2/950 0% |
| Breast Carcinoma | 0/144 0% | 6/3264 0% |
| Ovarian Carcinoma | 1/109 1% | 1/998 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Head and Neck Carcinoma | 0/85 0% | 2/1574 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 1/810 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 3/2550 0% |
| Gastric Carcinoma | 2/74 3% | 0/1809 0% |
| Kidney Carcinoma | 0/85 0% | 2/1862 0% |
| Other Blood Cancers | 0/61 0% | 2/2725 0% |
Mutation Distribution
Where TP53I3 is mutated · all tissues, split by cell line vs tissue
How many mutations in TP53I3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 309 mutations in TP53I3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|