Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,390 | 159 | 1,229 |
| Samples | 152 | 25 | 125 |
| Peptides | 162 | 18 | 142 |
Function
TPM1 · Tropomyosin 1
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022].
Isoforms & Proteins
17 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000403994 | P09493 | 117 | 92 |
| ENST00000357980 | F6UI89* | 107 | 92 |
| ENST00000560970 | A0A0S2Z4G6* | 104 | 87 |
| ENST00000559556 | P09493-9 | 103 | 89 |
| ENST00000561266 | P09493-6 | 95 | 78 |
| ENST00000267996 | P09493-7 | 94 | 80 |
| ENST00000288398 | P09493-10 | 91 | 77 |
| ENST00000358278 | P09493-3 | 90 | 79 |
| ENST00000334895 | P09493-5 | 87 | 71 |
| ENST00000558910 | H0YKJ4* | 87 | 71 |
| ENST00000559281 | H0YK48* | 87 | 71 |
| ENST00000559397 | P09493-8 | 81 | 70 |
| ENST00000317516 | F5H7S3* | 74 | 61 |
| ENST00000404484 | H7BYY1* | 73 | 63 |
| ENST00000560959 | B7Z596* | 73 | 63 |
| ENST00000610733 | A0A087WTJ7* | 26 | 23 |
| ENST00000559831 | H0YKX5* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 92 amino-acid changes on canonical ENST00000403994 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TPM1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TPM1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 2/7 29% | 0/13 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Endometrial Carcinoma | 1/42 2% | 11/612 2% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Melanoma | 1/210 0% | 17/1899 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 6/1390 0% |
| Colorectal Carcinoma | 3/143 2% | 22/3239 1% |
| Gastric Carcinoma | 1/74 1% | 8/1809 0% |
| Cervical Carcinoma | 2/35 6% | 0/422 0% |
| Bladder Carcinoma | 0/58 0% | 4/956 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 5/1592 0% |
| Other Solid Cancers | 0/94 0% | 5/1515 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Hepatocellular Carcinoma | 0/46 0% | 6/2210 0% |
| Neuroendocrine Tumour | 0/154 0% | 2/577 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 2/810 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Breast Carcinoma | 0/144 0% | 6/3264 0% |
| Ovarian Carcinoma | 0/109 0% | 2/998 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| Prostate Carcinoma | 0/13 0% | 3/2105 0% |
| Neuroblastoma | 1/87 1% | 1/1331 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Head and Neck Carcinoma | 0/85 0% | 2/1574 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
Mutation Distribution
Where TPM1 is mutated · all tissues, split by cell line vs tissue
How many mutations in TPM1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,390 mutations in TPM1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|