Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 980 | 51 | 924 |
| Samples | 167 | 16 | 148 |
| Peptides | 205 | 16 | 187 |
Function
TPM3 · Tropomyosin 3
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Isoforms & Proteins
12 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000368530 | A0A2R2Y2Q3* | 128 | 107 |
| ENST00000271850 | J3KN67* | 117 | 99 |
| ENST00000328159 | P06753-6 | 113 | 94 |
| ENST00000323144 | P06753-4 | 104 | 88 |
| ENST00000368531 | P06753-3 | 101 | 84 |
| ENST00000330188 | P06753-5 | 97 | 84 |
| ENST00000368533 | P06753-2 | 94 | 80 |
| ENST00000611659 | A0A087WWU8* | 89 | 75 |
| ENST00000302206 | P06753-7 | 57 | 52 |
| ENST00000341485 | P06753-4 | 40 | 32 |
| ENST00000651641 | P06753 | 22 | 21 |
| ENST00000341372 | Q5VU61* | 18 | 15 |
Gene Properties
Recurrent Mutations
All 94 amino-acid changes on canonical ENST00000328159 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TPM3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TPM3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 2/42 5% | 13/612 2% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Melanoma | 1/210 0% | 16/1899 1% |
| Colorectal Carcinoma | 1/143 1% | 26/3239 1% |
| Other Solid Cancers | 0/94 0% | 9/1515 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 7/1390 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 4/810 0% |
| Hepatocellular Carcinoma | 1/46 2% | 9/2210 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 5/1592 0% |
| Gastric Carcinoma | 0/74 0% | 8/1809 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Bladder Carcinoma | 0/58 0% | 4/956 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 10/2550 0% |
| Neuroendocrine Tumour | 1/154 1% | 1/577 0% |
| Breast Carcinoma | 0/144 0% | 9/3264 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Ovarian Carcinoma | 2/109 2% | 0/998 0% |
| Head and Neck Carcinoma | 1/85 1% | 2/1574 0% |
| B-Lymphoblastic Leukemia | 2/55 4% | 2/2640 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
| Prostate Carcinoma | 1/13 8% | 1/2105 0% |
| Neuroblastoma | 0/87 0% | 1/1331 0% |
| Kidney Carcinoma | 0/85 0% | 1/1862 0% |
Mutation Distribution
Where TPM3 is mutated · all tissues, split by cell line vs tissue
How many mutations in TPM3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 980 mutations in TPM3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|