Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 6,005 | 476 | 5,419 |
| Samples | 1,138 | 151 | 964 |
| Peptides | 769 | 111 | 686 |
Function
TPO · Thyroid peroxidase
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].
Isoforms & Proteins
7 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 700 amino-acid changes on canonical ENST00000329066 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TPO · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TPO – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 13/210 6% | 181/1899 10% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 29/612 5% |
| Hodgkins Lymphoma | 4/16 25% | 3/122 2% |
| Non-Small Cell Lung Carcinoma | 25/304 8% | 52/1390 4% |
| Gastric Carcinoma | 1/74 1% | 84/1809 5% |
| Other Solid Cancers | 4/94 4% | 68/1515 4% |
| Esophageal Carcinoma | 2/23 9% | 30/769 4% |
| Colorectal Carcinoma | 21/143 15% | 113/3239 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Neuroendocrine Tumour | 15/154 10% | 8/577 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 26/810 3% |
| Bladder Carcinoma | 1/58 2% | 28/956 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 59/2550 2% |
| Small Cell Lung Carcinoma | 2/9 22% | 14/752 2% |
| Cervical Carcinoma | 0/35 0% | 9/422 2% |
| Biliary Tract Carcinoma | 0/54 0% | 19/950 2% |
| Hepatocellular Carcinoma | 0/46 0% | 42/2210 2% |
| Mesothelioma | 4/62 6% | 0/165 0% |
| Plasma Cell Myeloma | 2/44 5% | 4/305 1% |
| Pancreatic Carcinoma | 2/89 2% | 26/1611 2% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Ewings Sarcoma | 3/63 5% | 2/262 1% |
| Head and Neck Carcinoma | 2/85 2% | 22/1574 1% |
| Glioma | 3/52 6% | 28/2127 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Non-Cancerous | 0/104 0% | 13/830 2% |
Mutation Distribution
Where TPO is mutated · all tissues, split by cell line vs tissue
How many mutations in TPO were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 6,005 mutations in TPO
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|