Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 215 | 20 | 194 |
| Samples | 211 | 20 | 190 |
| Peptides | 143 | 17 | 131 |
Function
TPTEP2-CSNK1E · TPTEP2-CSNK1E readthrough
This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000400206 | P49674 | 215 | 143 |
Gene Properties
Recurrent Mutations
All 143 amino-acid changes on canonical ENST00000400206 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TPTEP2-CSNK1E · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TPTEP2-CSNK1E – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Colorectal Carcinoma | 2/143 1% | 47/3239 1% |
| Gastric Carcinoma | 1/74 1% | 24/1809 1% |
| Endometrial Carcinoma | 1/42 2% | 7/612 1% |
| Melanoma | 0/210 0% | 20/1899 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 8/1390 1% |
| Hodgkins Lymphoma | 1/16 6% | 0/122 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Ovarian Carcinoma | 3/109 3% | 4/998 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 4/810 0% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Bladder Carcinoma | 0/58 0% | 4/956 0% |
| Head and Neck Carcinoma | 0/85 0% | 6/1574 0% |
| Kidney Carcinoma | 0/85 0% | 6/1862 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Other Sarcomas | 1/69 1% | 1/699 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 4/1592 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 6/2550 0% |
| Other Solid Cancers | 0/94 0% | 3/1515 0% |
| Pancreatic Carcinoma | 0/89 0% | 3/1611 0% |
| Breast Carcinoma | 1/144 1% | 4/3264 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Prostate Carcinoma | 0/13 0% | 2/2105 0% |
Mutation Distribution
Where TPTEP2-CSNK1E is mutated · all tissues, split by cell line vs tissue
How many mutations in TPTEP2-CSNK1E were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 215 mutations in TPTEP2-CSNK1E
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|