Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,125 | 146 | 970 |
| Samples | 304 | 58 | 243 |
| Peptides | 251 | 46 | 213 |
Function
TRAF3 · TNF receptor associated factor 3
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 231 amino-acid changes on canonical ENST00000392745 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TRAF3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TRAF3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 16/612 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Plasma Cell Myeloma | 1/44 2% | 4/305 1% |
| Melanoma | 5/210 2% | 24/1899 1% |
| Colorectal Carcinoma | 3/143 2% | 37/3239 1% |
| Gastric Carcinoma | 5/74 7% | 15/1809 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 2/94 2% | 13/1515 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 8/810 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 13/1390 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Head and Neck Carcinoma | 1/85 1% | 12/1574 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 11/2534 0% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 15/2550 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Ovarian Carcinoma | 1/109 1% | 4/998 0% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Hepatocellular Carcinoma | 1/46 2% | 8/2210 0% |
| Other Sarcomas | 3/69 4% | 0/699 0% |
| Glioma | 0/52 0% | 8/2127 0% |
Mutation Distribution
Where TRAF3 is mutated · all tissues, split by cell line vs tissue
How many mutations in TRAF3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,125 mutations in TRAF3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|