Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 384 | 32 | 346 |
| Samples | 371 | 31 | 335 |
| Peptides | 296 | 30 | 268 |
Function
TRIM6-TRIM34 · TRIM6-TRIM34 readthrough
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. [provided by RefSeq, Nov 2009].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000354852 | B2RNG4* | 384 | 296 |
Gene Properties
Recurrent Mutations
All 296 amino-acid changes on canonical ENST00000354852 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TRIM6-TRIM34 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TRIM6-TRIM34 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 1/42 2% | 19/612 3% |
| Melanoma | 1/210 0% | 60/1899 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 20/810 2% |
| Gastric Carcinoma | 0/74 0% | 31/1809 2% |
| Colorectal Carcinoma | 4/143 3% | 47/3239 1% |
| Hodgkins Lymphoma | 1/16 6% | 1/122 1% |
| Other Solid Cancers | 0/94 0% | 19/1515 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 10/1390 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 24/2550 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Bladder Carcinoma | 0/58 0% | 7/956 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Glioma | 1/52 2% | 11/2127 1% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Prostate Carcinoma | 0/13 0% | 10/2105 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Breast Carcinoma | 4/144 3% | 11/3264 0% |
| Ovarian Carcinoma | 1/109 1% | 3/998 0% |
| Kidney Carcinoma | 1/85 1% | 6/1862 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 5/1592 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
Mutation Distribution
Where TRIM6-TRIM34 is mutated · all tissues, split by cell line vs tissue
How many mutations in TRIM6-TRIM34 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 384 mutations in TRIM6-TRIM34
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|