Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 270 | 71 | 195 |
| Samples | 260 | 67 | 190 |
| Peptides | 192 | 44 | 156 |
Function
TRIM68 · Tripartite motif containing 68
This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a 'really interesting new gene' (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000300747 | Q6AZZ1 | 270 | 192 |
Gene Properties
Recurrent Mutations
All 192 amino-acid changes on canonical ENST00000300747 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TRIM68 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TRIM68 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Endometrial Carcinoma | 2/42 5% | 14/612 2% |
| Melanoma | 5/210 2% | 26/1899 1% |
| Squamous Cell Lung Carcinoma | 8/57 14% | 3/810 0% |
| Colorectal Carcinoma | 14/143 10% | 26/3239 1% |
| Gastric Carcinoma | 0/74 0% | 22/1809 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 9/1390 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 1/94 1% | 13/1515 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Cervical Carcinoma | 1/35 3% | 2/422 0% |
| Head and Neck Carcinoma | 1/85 1% | 8/1574 1% |
| Glioma | 0/52 0% | 11/2127 1% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Pancreatic Carcinoma | 2/89 2% | 5/1611 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 4/1592 0% |
| Biliary Tract Carcinoma | 1/54 2% | 2/950 0% |
| Breast Carcinoma | 2/144 1% | 8/3264 0% |
| Neuroendocrine Tumour | 2/154 1% | 0/577 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 4/2534 0% |
| Kidney Carcinoma | 2/85 2% | 3/1862 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
Mutation Distribution
Where TRIM68 is mutated · all tissues, split by cell line vs tissue
How many mutations in TRIM68 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 270 mutations in TRIM68
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|