Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 497 | 70 | 426 |
| Samples | 169 | 36 | 132 |
| Peptides | 111 | 23 | 93 |
Function
TSPAN8 · Tetraspanin 8
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 111 amino-acid changes on canonical ENST00000247829 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TSPAN8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TSPAN8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 9/612 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Melanoma | 3/210 1% | 28/1899 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Bladder Carcinoma | 0/58 0% | 11/956 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 4/810 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 8/1390 1% |
| Colorectal Carcinoma | 5/143 4% | 10/3239 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 7/1592 0% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Other Sarcomas | 1/69 1% | 2/699 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Non-Cancerous | 1/104 1% | 2/830 0% |
| Other Solid Cancers | 0/94 0% | 5/1515 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Gastric Carcinoma | 0/74 0% | 4/1809 0% |
| Ovarian Carcinoma | 0/109 0% | 2/998 0% |
| Breast Carcinoma | 4/144 3% | 2/3264 0% |
| Other Blood Cancers | 0/61 0% | 5/2725 0% |
Mutation Distribution
Where TSPAN8 is mutated · all tissues, split by cell line vs tissue
How many mutations in TSPAN8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 497 mutations in TSPAN8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|