Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,436 | 207 | 1,219 |
| Samples | 237 | 53 | 181 |
| Peptides | 205 | 43 | 169 |
Function
TXNRD2 · Thioredoxin reductase 2
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017].
Isoforms & Proteins
9 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000400521 | Q9NNW7 | 240 | 167 |
| ENST00000400519 | - | 210 | 149 |
| ENST00000400518 | - | 205 | 144 |
| ENST00000400525 | - | 200 | 140 |
| ENST00000542719 | Q9NNW7-3 | 173 | 119 |
| ENST00000334363 | E7EWK1* | 127 | 96 |
| ENST00000491939 | A0A096LPD9* | 121 | 90 |
| ENST00000462330 | - | 80 | 49 |
| ENST00000485358 | - | 80 | 49 |
Gene Properties
Recurrent Mutations
All 167 amino-acid changes on canonical ENST00000400521 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TXNRD2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TXNRD2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 20/612 3% |
| Rhabdomyosarcoma | 0/33 0% | 7/171 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Hodgkins Lymphoma | 3/16 19% | 0/122 0% |
| Melanoma | 2/210 1% | 29/1899 2% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Ovarian Carcinoma | 5/109 5% | 6/998 1% |
| Colorectal Carcinoma | 6/143 4% | 27/3239 1% |
| Bladder Carcinoma | 0/58 0% | 7/956 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Glioma | 1/52 2% | 12/2127 1% |
| Gastric Carcinoma | 1/74 1% | 10/1809 1% |
| Other Solid Cancers | 0/94 0% | 9/1515 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 4/1390 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 6/1592 0% |
| Hepatocellular Carcinoma | 1/46 2% | 7/2210 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Head and Neck Carcinoma | 2/85 2% | 3/1574 0% |
| Pancreatic Carcinoma | 2/89 2% | 3/1611 0% |
| Breast Carcinoma | 2/144 1% | 7/3264 0% |
| Kidney Carcinoma | 2/85 2% | 1/1862 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 2/2534 0% |
Mutation Distribution
Where TXNRD2 is mutated · all tissues, split by cell line vs tissue
How many mutations in TXNRD2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,436 mutations in TXNRD2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|