Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 436 | 33 | 401 |
| Samples | 253 | 30 | 222 |
| Peptides | 209 | 31 | 178 |
Function
TYW1B · TRNA-yW synthesizing protein 1 homolog B
Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, Apr 2014].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000620995 | Q6NUM6 | 261 | 191 |
| ENST00000612372 | A0A087WWV6* | 175 | 119 |
Gene Properties
Recurrent Mutations
All 191 amino-acid changes on canonical ENST00000620995 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TYW1B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TYW1B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 3/42 7% | 19/612 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 12/810 1% |
| Melanoma | 1/210 0% | 29/1899 2% |
| Gastric Carcinoma | 1/74 1% | 22/1809 1% |
| Bladder Carcinoma | 1/58 2% | 11/956 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Osteosarcoma | 0/45 0% | 2/166 1% |
| Other Solid Cancers | 1/94 1% | 12/1515 1% |
| Colorectal Carcinoma | 3/143 2% | 24/3239 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 10/1390 1% |
| Cervical Carcinoma | 1/35 3% | 2/422 0% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Neuroendocrine Tumour | 4/154 3% | 0/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Glioma | 0/52 0% | 10/2127 0% |
| Ovarian Carcinoma | 0/109 0% | 5/998 0% |
| Hepatocellular Carcinoma | 1/46 2% | 8/2210 0% |
| Breast Carcinoma | 1/144 1% | 12/3264 0% |
| Head and Neck Carcinoma | 1/85 1% | 5/1574 0% |
| Pancreatic Carcinoma | 0/89 0% | 6/1611 0% |
| Prostate Carcinoma | 0/13 0% | 7/2105 0% |
| Kidney Carcinoma | 1/85 1% | 5/1862 0% |
| Other Blood Cancers | 1/61 2% | 7/2725 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 2/2534 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
| B-Lymphoblastic Leukemia | 1/55 2% | 0/2640 0% |
Mutation Distribution
Where TYW1B is mutated · all tissues, split by cell line vs tissue
How many mutations in TYW1B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 436 mutations in TYW1B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|