Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,881 | 305 | 1,567 |
| Samples | 634 | 129 | 502 |
| Peptides | 472 | 95 | 399 |
Function
UNC45B · Unc-45 myosin chaperone B
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 460 amino-acid changes on canonical ENST00000394570 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in UNC45B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in UNC45B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 12/40 30% | 0/0 0% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 25/612 4% |
| Melanoma | 14/210 7% | 70/1899 4% |
| Other Solid Cancers | 4/94 4% | 55/1515 4% |
| Non-Small Cell Lung Carcinoma | 22/304 7% | 40/1390 3% |
| Colorectal Carcinoma | 18/143 13% | 76/3239 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 15/810 2% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Neuroendocrine Tumour | 10/154 6% | 5/577 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 14/752 2% |
| Other Sarcomas | 4/69 6% | 9/699 1% |
| Gastric Carcinoma | 1/74 1% | 29/1809 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Bladder Carcinoma | 0/58 0% | 13/956 1% |
| Non-Cancerous | 1/104 1% | 11/830 1% |
| Hepatocellular Carcinoma | 1/46 2% | 26/2210 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Mesothelioma | 0/62 0% | 2/165 1% |
| Glioma | 0/52 0% | 18/2127 1% |
| Biliary Tract Carcinoma | 1/54 2% | 6/950 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 13/2550 1% |
| Breast Carcinoma | 2/144 1% | 17/3264 1% |
| Pancreatic Carcinoma | 2/89 2% | 7/1611 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
Mutation Distribution
Where UNC45B is mutated · all tissues, split by cell line vs tissue
How many mutations in UNC45B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,881 mutations in UNC45B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|