Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 699 | 91 | 598 |
| Samples | 326 | 57 | 264 |
| Peptides | 260 | 39 | 221 |
Function
USP10 · Ubiquitin specific peptidase 10
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 255 amino-acid changes on canonical ENST00000219473 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in USP10 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in USP10 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 17/612 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Colorectal Carcinoma | 7/143 5% | 44/3239 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Melanoma | 3/210 1% | 24/1899 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 21/1592 1% |
| Bladder Carcinoma | 2/58 3% | 10/956 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 8/1390 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 5/810 1% |
| Gastric Carcinoma | 5/74 7% | 12/1809 1% |
| Hepatocellular Carcinoma | 0/46 0% | 20/2210 1% |
| Other Solid Cancers | 0/94 0% | 13/1515 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Ewings Sarcoma | 2/63 3% | 0/262 0% |
| Pancreatic Carcinoma | 2/89 2% | 8/1611 0% |
| Head and Neck Carcinoma | 1/85 1% | 8/1574 1% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Kidney Carcinoma | 1/85 1% | 8/1862 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Other Sarcomas | 1/69 1% | 2/699 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 9/2550 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Breast Carcinoma | 2/144 1% | 7/3264 0% |
Mutation Distribution
Where USP10 is mutated · all tissues, split by cell line vs tissue
How many mutations in USP10 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 699 mutations in USP10
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|