Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 124 | 73 | 0 |
| Samples | 80 | 67 | 0 |
| Peptides | 119 | 69 | 0 |
Function
VARS1 · Valyl-tRNA synthetase 1
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000375663 | P26640 | 124 | 119 |
Gene Properties
Recurrent Mutations
All 119 amino-acid changes on canonical ENST00000375663 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in VARS1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in VARS1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Endometrial Carcinoma | 6/42 14% | 1/612 0% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 1/1390 0% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Ovarian Carcinoma | 3/109 3% | 1/998 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Melanoma | 2/210 1% | 3/1899 0% |
| Colorectal Carcinoma | 7/143 5% | 1/3239 0% |
| Bladder Carcinoma | 1/58 2% | 1/956 0% |
| Gastric Carcinoma | 2/74 3% | 1/1809 0% |
| Prostate Carcinoma | 2/13 15% | 1/2105 0% |
| Neuroendocrine Tumour | 1/154 1% | 0/577 0% |
| Other Sarcomas | 1/69 1% | 0/699 0% |
| Hepatocellular Carcinoma | 3/46 7% | 0/2210 0% |
| Head and Neck Carcinoma | 1/85 1% | 1/1574 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 0/810 0% |
| Kidney Carcinoma | 2/85 2% | 0/1862 0% |
| Biliary Tract Carcinoma | 1/54 2% | 0/950 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 0/2534 0% |
| B-Lymphoblastic Leukemia | 2/55 4% | 0/2640 0% |
| Pancreatic Carcinoma | 0/89 0% | 1/1611 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 0/1592 0% |
| Breast Carcinoma | 2/144 1% | 0/3264 0% |
Mutation Distribution
Where VARS1 is mutated · all tissues, split by cell line vs tissue
How many mutations in VARS1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 124 mutations in VARS1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|