Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 372 | 61 | 303 |
| Samples | 355 | 57 | 292 |
| Peptides | 238 | 39 | 204 |
Function
VNN1 · Vanin 1
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000367928 | O95497 | 372 | 238 |
Gene Properties
Recurrent Mutations
All 238 amino-acid changes on canonical ENST00000367928 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in VNN1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in VNN1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Unknown | 0/10 0% | 2/29 7% |
| Endometrial Carcinoma | 5/42 12% | 20/612 3% |
| Melanoma | 5/210 2% | 48/1899 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 23/1390 2% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 12/810 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 12/752 2% |
| Ovarian Carcinoma | 3/109 3% | 11/998 1% |
| Colorectal Carcinoma | 7/143 5% | 34/3239 1% |
| Other Solid Cancers | 2/94 2% | 17/1515 1% |
| Other Sarcomas | 3/69 4% | 5/699 1% |
| Gastric Carcinoma | 3/74 4% | 14/1809 1% |
| Mesothelioma | 1/62 2% | 1/165 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 19/2550 1% |
| Esophageal Carcinoma | 2/23 9% | 4/769 1% |
| Neuroendocrine Tumour | 4/154 3% | 0/577 0% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Head and Neck Carcinoma | 0/85 0% | 8/1574 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Breast Carcinoma | 0/144 0% | 13/3264 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Pancreatic Carcinoma | 1/89 1% | 5/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 6/2534 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroblastoma | 0/87 0% | 4/1331 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
Mutation Distribution
Where VNN1 is mutated · all tissues, split by cell line vs tissue
How many mutations in VNN1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 372 mutations in VNN1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|