WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Q96NZ8 WFKN1_HUMANStats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 267 | 71 | 191 |
| Samples | 246 | 64 | 179 |
| Peptides | 203 | 57 | 151 |
Function
WFIKKN1 · WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000319070 | Q96NZ8 | 267 | 203 |
Gene Properties
Recurrent Mutations
All 203 amino-acid changes on canonical ENST00000319070 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in WFIKKN1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in WFIKKN1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 11/612 2% |
| Hodgkins Lymphoma | 1/16 6% | 1/122 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 22/1592 1% |
| Melanoma | 4/210 2% | 21/1899 1% |
| Gastric Carcinoma | 2/74 3% | 20/1809 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Colorectal Carcinoma | 6/143 4% | 28/3239 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 9/1390 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Biliary Tract Carcinoma | 1/54 2% | 5/950 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 12/2550 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Cervical Carcinoma | 1/35 3% | 1/422 0% |
| Other Solid Cancers | 1/94 1% | 6/1515 0% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Ovarian Carcinoma | 3/109 3% | 1/998 0% |
| Hepatocellular Carcinoma | 2/46 4% | 6/2210 0% |
| Bladder Carcinoma | 2/58 3% | 1/956 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Breast Carcinoma | 0/144 0% | 9/3264 0% |
| Head and Neck Carcinoma | 1/85 1% | 3/1574 0% |
| Kidney Carcinoma | 2/85 2% | 2/1862 0% |
Mutation Distribution
Where WFIKKN1 is mutated · all tissues, split by cell line vs tissue
How many mutations in WFIKKN1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 267 mutations in WFIKKN1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|