Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 866 | 137 | 705 |
| Samples | 520 | 106 | 404 |
| Peptides | 428 | 74 | 356 |
Function
YTHDC2 · YTH N6-methyladenosine RNA binding protein C2
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 423 amino-acid changes on canonical ENST00000161863 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in YTHDC2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in YTHDC2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 4/42 10% | 33/612 5% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Unknown | 0/10 0% | 2/29 7% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Melanoma | 8/210 4% | 52/1899 3% |
| Colorectal Carcinoma | 18/143 13% | 63/3239 2% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 9/422 2% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 21/1390 2% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 15/810 2% |
| Bladder Carcinoma | 2/58 3% | 16/956 2% |
| Neuroendocrine Tumour | 11/154 7% | 1/577 0% |
| Gastric Carcinoma | 1/74 1% | 29/1809 2% |
| Mesothelioma | 2/62 3% | 1/165 1% |
| Other Solid Cancers | 0/94 0% | 21/1515 1% |
| Hepatocellular Carcinoma | 0/46 0% | 22/2210 1% |
| Rhabdomyosarcoma | 2/33 6% | 0/171 0% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Ovarian Carcinoma | 7/109 6% | 3/998 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Head and Neck Carcinoma | 1/85 1% | 13/1574 1% |
| Biliary Tract Carcinoma | 0/54 0% | 8/950 1% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| Glioma | 2/52 4% | 12/2127 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 8/1592 0% |
Mutation Distribution
Where YTHDC2 is mutated · all tissues, split by cell line vs tissue
How many mutations in YTHDC2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 866 mutations in YTHDC2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|