YWHAZ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta P63104 1433Z_HUMANStats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 811 | 77 | 732 |
| Samples | 90 | 15 | 73 |
| Peptides | 84 | 9 | 73 |
Function
YWHAZ · Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008].
Isoforms & Proteins
12 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000395958 | P63104 | 89 | 71 |
| ENST00000353245 | P63104 | 80 | 65 |
| ENST00000395951 | P63104 | 79 | 65 |
| ENST00000395953 | P63104 | 79 | 65 |
| ENST00000395956 | P63104 | 79 | 65 |
| ENST00000395957 | P63104 | 79 | 65 |
| ENST00000419477 | P63104 | 79 | 65 |
| ENST00000457309 | P63104 | 79 | 65 |
| ENST00000395948 | B0AZS6* | 53 | 44 |
| ENST00000522542 | P63104-2 | 41 | 33 |
| ENST00000521309 | B7Z2E6* | 37 | 30 |
| ENST00000522819 | B7Z2E6* | 37 | 30 |
Gene Properties
Recurrent Mutations
All 71 amino-acid changes on canonical ENST00000395958 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in YWHAZ · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in YWHAZ – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 7/1592 0% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 3/1390 0% |
| Breast Carcinoma | 4/144 3% | 6/3264 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Melanoma | 1/210 0% | 4/1899 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 2/810 0% |
| Gastric Carcinoma | 0/74 0% | 4/1809 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| Colorectal Carcinoma | 0/143 0% | 5/3239 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Head and Neck Carcinoma | 0/85 0% | 2/1574 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 3/2550 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
| Other Blood Cancers | 0/61 0% | 1/2725 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 1/2534 0% |
Mutation Distribution
Where YWHAZ is mutated · all tissues, split by cell line vs tissue
How many mutations in YWHAZ were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 811 mutations in YWHAZ
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|