Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 724 | 127 | 588 |
| Samples | 453 | 95 | 352 |
| Peptides | 312 | 64 | 263 |
Function
ZAP70 · Zeta chain of T cell receptor associated protein kinase 70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 309 amino-acid changes on canonical ENST00000264972 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZAP70 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZAP70 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Endometrial Carcinoma | 8/42 19% | 16/612 3% |
| Colorectal Carcinoma | 20/143 14% | 74/3239 2% |
| Melanoma | 8/210 4% | 42/1899 2% |
| Non-Small Cell Lung Carcinoma | 17/304 6% | 21/1390 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 12/810 1% |
| Gastric Carcinoma | 1/74 1% | 29/1809 2% |
| Non-Cancerous | 2/104 2% | 9/830 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Ovarian Carcinoma | 5/109 5% | 6/998 1% |
| Other Solid Cancers | 0/94 0% | 15/1515 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Glioma | 1/52 2% | 18/2127 1% |
| Hepatocellular Carcinoma | 1/46 2% | 17/2210 1% |
| Head and Neck Carcinoma | 2/85 2% | 11/1574 1% |
| Other Sarcomas | 1/69 1% | 5/699 1% |
| Esophageal Carcinoma | 2/23 9% | 4/769 1% |
| Neuroendocrine Tumour | 5/154 3% | 0/577 0% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Pancreatic Carcinoma | 1/89 1% | 8/1611 0% |
| Prostate Carcinoma | 2/13 15% | 9/2105 0% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 9/2534 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 8/2550 0% |
| Kidney Carcinoma | 0/85 0% | 8/1862 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
Mutation Distribution
Where ZAP70 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZAP70 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 724 mutations in ZAP70
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|