Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 741 | 110 | 623 |
| Samples | 311 | 63 | 242 |
| Peptides | 244 | 44 | 205 |
Function
ZCCHC8 · Zinc finger CCHC-type containing 8
This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 233 amino-acid changes on canonical ENST00000633063 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZCCHC8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZCCHC8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 15/612 2% |
| Cervical Carcinoma | 5/35 14% | 6/422 1% |
| Hodgkins Lymphoma | 3/16 19% | 0/122 0% |
| Bladder Carcinoma | 6/58 10% | 13/956 1% |
| Melanoma | 3/210 1% | 33/1899 2% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Other Solid Cancers | 0/94 0% | 21/1515 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 16/1390 1% |
| Colorectal Carcinoma | 11/143 8% | 30/3239 1% |
| Meningioma | 0/3 0% | 3/252 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Gastric Carcinoma | 1/74 1% | 19/1809 1% |
| Neuroendocrine Tumour | 5/154 3% | 2/577 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 5/810 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Other Sarcomas | 0/69 0% | 6/699 1% |
| Head and Neck Carcinoma | 0/85 0% | 10/1574 1% |
| Non-Cancerous | 2/104 2% | 3/830 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Hepatocellular Carcinoma | 1/46 2% | 10/2210 0% |
| Ovarian Carcinoma | 1/109 1% | 4/998 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Biliary Tract Carcinoma | 2/54 4% | 1/950 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Breast Carcinoma | 1/144 1% | 8/3264 0% |
| Kidney Carcinoma | 0/85 0% | 4/1862 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 5/2534 0% |
Mutation Distribution
Where ZCCHC8 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZCCHC8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 741 mutations in ZCCHC8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|