Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,750 | 548 | 3,099 |
| Samples | 1,220 | 246 | 960 |
| Peptides | 903 | 173 | 744 |
Function
ZFPM2 · Zinc finger protein, FOG family member 2
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 893 amino-acid changes on canonical ENST00000407775 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZFPM2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZFPM2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Melanoma | 31/210 15% | 212/1899 11% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Oral Cavity Carcinoma | 4/54 7% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 35/304 12% | 87/1390 6% |
| Endometrial Carcinoma | 6/42 14% | 33/612 5% |
| Hodgkins Lymphoma | 2/16 12% | 6/122 5% |
| Unknown | 0/10 0% | 2/29 7% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 8/57 14% | 29/810 4% |
| Colorectal Carcinoma | 26/143 18% | 117/3239 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Neuroendocrine Tumour | 20/154 13% | 3/577 1% |
| Gastric Carcinoma | 10/74 14% | 49/1809 3% |
| Hepatocellular Carcinoma | 6/46 13% | 63/2210 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Other Solid Cancers | 3/94 3% | 46/1515 3% |
| Small Cell Lung Carcinoma | 2/9 22% | 20/752 3% |
| Esophageal Carcinoma | 2/23 9% | 19/769 2% |
| Bladder Carcinoma | 2/58 3% | 24/956 3% |
| Osteosarcoma | 5/45 11% | 0/166 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 48/2550 2% |
| Ovarian Carcinoma | 6/109 6% | 11/998 1% |
| Ewings Sarcoma | 2/63 3% | 3/262 1% |
| Cervical Carcinoma | 2/35 6% | 5/422 1% |
| Rhabdomyosarcoma | 0/33 0% | 3/171 2% |
| Plasma Cell Myeloma | 1/44 2% | 4/305 1% |
| Breast Carcinoma | 11/144 8% | 37/3264 1% |
| Head and Neck Carcinoma | 2/85 2% | 18/1574 1% |
Mutation Distribution
Where ZFPM2 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZFPM2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,750 mutations in ZFPM2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|