Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,070 | 223 | 1,826 |
| Samples | 572 | 93 | 472 |
| Peptides | 428 | 66 | 373 |
Function
ZIM2 · Zinc finger imprinted 2
In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000593711 | Q9NZV7 | 574 | 372 |
| ENST00000599935 | Q9NZV7 | 573 | 371 |
| ENST00000601070 | Q9NZV7 | 573 | 371 |
| ENST00000629319 | A0A8I5KWX0* | 257 | 168 |
| ENST00000593931 | M0QXH8* | 93 | 58 |
Gene Properties
Recurrent Mutations
All 372 amino-acid changes on canonical ENST00000593711 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZIM2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZIM2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Melanoma | 7/210 3% | 97/1899 5% |
| Other Solid Cancers | 8/94 9% | 49/1515 3% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 27/810 3% |
| Endometrial Carcinoma | 3/42 7% | 17/612 3% |
| Non-Small Cell Lung Carcinoma | 18/304 6% | 29/1390 2% |
| Neuroendocrine Tumour | 17/154 11% | 3/577 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 17/752 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Colorectal Carcinoma | 6/143 4% | 55/3239 2% |
| Esophageal Carcinoma | 2/23 9% | 11/769 1% |
| Biliary Tract Carcinoma | 1/54 2% | 15/950 2% |
| Gastric Carcinoma | 1/74 1% | 25/1809 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Bladder Carcinoma | 1/58 2% | 10/956 1% |
| Other Sarcomas | 3/69 4% | 5/699 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 26/2550 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Head and Neck Carcinoma | 3/85 4% | 13/1574 1% |
| Pancreatic Carcinoma | 3/89 3% | 12/1611 1% |
| Non-Cancerous | 2/104 2% | 5/830 1% |
| Ovarian Carcinoma | 1/109 1% | 7/998 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Breast Carcinoma | 2/144 1% | 10/3264 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Kidney Carcinoma | 2/85 2% | 4/1862 0% |
Mutation Distribution
Where ZIM2 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZIM2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 50 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,070 mutations in ZIM2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|