Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 846 | 150 | 693 |
| Samples | 280 | 66 | 211 |
| Peptides | 247 | 57 | 197 |
Function
ZNF189 · Zinc finger protein 189
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000339664 | O75820 | 305 | 217 |
| ENST00000374861 | O75820-2 | 264 | 203 |
| ENST00000259395 | O75820-4 | 246 | 190 |
| ENST00000615466 | A0A087X0K2* | 31 | 21 |
Gene Properties
Recurrent Mutations
All 217 amino-acid changes on canonical ENST00000339664 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZNF189 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZNF189 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 20/612 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Germ Cell Tumour | 0/25 0% | 3/169 2% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Melanoma | 9/210 4% | 19/1899 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 27/2550 1% |
| Colorectal Carcinoma | 5/143 4% | 33/3239 1% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Neuroendocrine Tumour | 4/154 3% | 4/577 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 6/810 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Bladder Carcinoma | 1/58 2% | 6/956 1% |
| Other Solid Cancers | 4/94 4% | 7/1515 0% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Head and Neck Carcinoma | 1/85 1% | 10/1574 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 9/1390 1% |
| Ovarian Carcinoma | 3/109 3% | 4/998 0% |
| Gastric Carcinoma | 2/74 3% | 8/1809 0% |
| Other Sarcomas | 0/69 0% | 4/699 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Non-Cancerous | 1/104 1% | 3/830 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| B-Cell Non-Hodgkins Lymphoma | 6/88 7% | 4/2534 0% |
| Prostate Carcinoma | 0/13 0% | 8/2105 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
Mutation Distribution
Where ZNF189 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZNF189 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 846 mutations in ZNF189
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|