Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,119 | 173 | 1,853 |
| Samples | 286 | 46 | 229 |
| Peptides | 252 | 37 | 218 |
Function
ZNF195 · Zinc finger protein 195
This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromosome 11p15.5, next to an imprinted domain that is associated with maternal-specific loss of heterozygosity in Wilms' tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Isoforms & Proteins
10 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000399602 | O14628 | 319 | 223 |
| ENST00000620374 | A0A087WT67* | 285 | 210 |
| ENST00000526601 | O14628-6 | 283 | 208 |
| ENST00000005082 | O14628-5 | 282 | 207 |
| ENST00000343338 | O14628-7 | 271 | 197 |
| ENST00000354599 | O14628-4 | 271 | 197 |
| ENST00000429541 | O14628-7 | 271 | 197 |
| ENST00000438262 | O14628-8 | 46 | 30 |
| ENST00000618467 | O14628-8 | 46 | 30 |
| ENST00000528796 | E9PPF8* | 45 | 29 |
Gene Properties
Recurrent Mutations
All 224 amino-acid changes on canonical ENST00000399602 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZNF195 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZNF195 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 5/42 12% | 30/612 5% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Melanoma | 2/210 1% | 39/1899 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Colorectal Carcinoma | 14/143 10% | 36/3239 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 2/94 2% | 13/1515 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Hepatocellular Carcinoma | 0/46 0% | 19/2210 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 11/1390 1% |
| Gastric Carcinoma | 0/74 0% | 12/1809 1% |
| Bladder Carcinoma | 1/58 2% | 5/956 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Ovarian Carcinoma | 4/109 4% | 2/998 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Glioma | 2/52 4% | 7/2127 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Other Sarcomas | 2/69 3% | 1/699 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 6/1592 0% |
| Kidney Carcinoma | 1/85 1% | 6/1862 0% |
| Breast Carcinoma | 2/144 1% | 9/3264 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
Mutation Distribution
Where ZNF195 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZNF195 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,119 mutations in ZNF195
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|