Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 976 | 149 | 822 |
| Samples | 368 | 75 | 292 |
| Peptides | 313 | 54 | 264 |
Function
ZNF197 · Zinc finger protein 197
This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 305 amino-acid changes on canonical ENST00000344387 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZNF197 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZNF197 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 26/612 4% |
| Hodgkins Lymphoma | 4/16 25% | 2/122 2% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Unknown | 1/10 10% | 0/29 0% |
| Melanoma | 5/210 2% | 39/1899 2% |
| Colorectal Carcinoma | 11/143 8% | 44/3239 1% |
| Bladder Carcinoma | 3/58 5% | 12/956 1% |
| Non-Cancerous | 0/104 0% | 12/830 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Gastric Carcinoma | 2/74 3% | 20/1809 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 6/1390 0% |
| Ovarian Carcinoma | 1/109 1% | 9/998 1% |
| Cervical Carcinoma | 2/35 6% | 2/422 0% |
| Other Solid Cancers | 0/94 0% | 13/1515 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 17/2550 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Thyroid Gland Carcinoma | 4/45 9% | 5/1592 0% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Glioma | 0/52 0% | 11/2127 1% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Kidney Carcinoma | 0/85 0% | 9/1862 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
Mutation Distribution
Where ZNF197 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZNF197 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 976 mutations in ZNF197
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|