Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 279 | 71 | 199 |
| Samples | 267 | 67 | 192 |
| Peptides | 193 | 43 | 152 |
Function
ZNF25 · Zinc finger protein 25
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000302609 | P17030 | 279 | 193 |
Gene Properties
Recurrent Mutations
All 193 amino-acid changes on canonical ENST00000302609 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZNF25 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZNF25 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 14/612 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 14/810 2% |
| Other Solid Cancers | 2/94 2% | 23/1515 2% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 16/1390 1% |
| Melanoma | 2/210 1% | 25/1899 1% |
| Bladder Carcinoma | 1/58 2% | 11/956 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Gastric Carcinoma | 3/74 4% | 14/1809 1% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Colorectal Carcinoma | 9/143 6% | 20/3239 1% |
| Neuroendocrine Tumour | 5/154 3% | 1/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Biliary Tract Carcinoma | 3/54 6% | 3/950 0% |
| Ovarian Carcinoma | 4/109 4% | 2/998 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Neuroblastoma | 3/87 3% | 4/1331 0% |
| Hepatocellular Carcinoma | 2/46 4% | 8/2210 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Head and Neck Carcinoma | 3/85 4% | 4/1574 0% |
| Breast Carcinoma | 4/144 3% | 7/3264 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 2/1592 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 5/2550 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
Mutation Distribution
Where ZNF25 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZNF25 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 279 mutations in ZNF25
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|