Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 588 | 99 | 481 |
| Samples | 205 | 47 | 151 |
| Peptides | 195 | 35 | 157 |
Function
ZNF397 · Zinc finger protein 397
This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 143 amino-acid changes on canonical ENST00000330501 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZNF397 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZNF397 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 15/612 2% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Melanoma | 3/210 1% | 26/1899 1% |
| Colorectal Carcinoma | 10/143 7% | 26/3239 1% |
| Rhabdomyosarcoma | 2/33 6% | 0/171 0% |
| Gastric Carcinoma | 4/74 5% | 13/1809 1% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 8/1390 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 17/2550 1% |
| Ewings Sarcoma | 2/63 3% | 0/262 0% |
| Bladder Carcinoma | 1/58 2% | 5/956 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Hepatocellular Carcinoma | 2/46 4% | 6/2210 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Head and Neck Carcinoma | 1/85 1% | 3/1574 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Breast Carcinoma | 0/144 0% | 7/3264 0% |
| Other Solid Cancers | 0/94 0% | 3/1515 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| Pancreatic Carcinoma | 2/89 2% | 0/1611 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 0/810 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Prostate Carcinoma | 1/13 8% | 1/2105 0% |
Mutation Distribution
Where ZNF397 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZNF397 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 588 mutations in ZNF397
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|