Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 94 | 14 | 80 |
| Samples | 93 | 14 | 79 |
| Peptides | 74 | 13 | 61 |
Function
ZNF816-ZNF321P · ZNF816-ZNF321P readthrough
This locus represents naturally occurring read-through transcription between the zinc finger protein 816 (ZNF816) gene and the zinc finger protein 321 (ZNF321) pseudogene on chromosome 19. The read-through transcript encodes a KRAB domain-containing protein that shares sequence identity with the upstream gene product, but it contains a distinct C-terminus encoded by exon structure from the downstream pseudogene. [provided by RefSeq, Jan 2011].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000391777 | A0A0X1KG74* | 94 | 74 |
Gene Properties
Recurrent Mutations
All 74 amino-acid changes on canonical ENST00000391777 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZNF816-ZNF321P · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZNF816-ZNF321P – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Bladder Carcinoma | 1/58 2% | 6/956 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 7/1390 0% |
| Hepatocellular Carcinoma | 1/46 2% | 11/2210 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Colorectal Carcinoma | 0/143 0% | 11/3239 0% |
| Gastric Carcinoma | 0/74 0% | 6/1809 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Melanoma | 1/210 0% | 5/1899 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 1/810 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Other Solid Cancers | 0/94 0% | 3/1515 0% |
| Ovarian Carcinoma | 1/109 1% | 1/998 0% |
| Breast Carcinoma | 1/144 1% | 4/3264 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Biliary Tract Carcinoma | 1/54 2% | 0/950 0% |
| Glioma | 0/52 0% | 2/2127 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 1/2534 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
| Head and Neck Carcinoma | 0/85 0% | 1/1574 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
| Kidney Carcinoma | 0/85 0% | 1/1862 0% |
Mutation Distribution
Where ZNF816-ZNF321P is mutated · all tissues, split by cell line vs tissue
How many mutations in ZNF816-ZNF321P were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 94 mutations in ZNF816-ZNF321P
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|