Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 330 | 41 | 284 |
| Samples | 225 | 31 | 190 |
| Peptides | 184 | 23 | 163 |
Function
ZUP1 · Zinc finger containing ubiquitin peptidase 1
This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. 'endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 175 amino-acid changes on canonical ENST00000368576 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ZUP1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ZUP1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Neuroendocrine Tumour | 5/154 3% | 11/577 2% |
| Endometrial Carcinoma | 3/42 7% | 10/612 2% |
| Melanoma | 5/210 2% | 23/1899 1% |
| Colorectal Carcinoma | 7/143 5% | 26/3239 1% |
| Gastric Carcinoma | 1/74 1% | 14/1809 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 6/810 1% |
| Other Solid Cancers | 0/94 0% | 11/1515 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Cervical Carcinoma | 2/35 6% | 1/422 0% |
| Hepatocellular Carcinoma | 0/46 0% | 13/2210 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 10/2550 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 6/1390 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Other Sarcomas | 1/69 1% | 2/699 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Pancreatic Carcinoma | 0/89 0% | 5/1611 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Kidney Carcinoma | 0/85 0% | 5/1862 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 4/1592 0% |
| Head and Neck Carcinoma | 0/85 0% | 4/1574 0% |
| Breast Carcinoma | 0/144 0% | 8/3264 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Prostate Carcinoma | 2/13 15% | 2/2105 0% |
| Glioma | 2/52 4% | 2/2127 0% |
| Other Blood Cancers | 0/61 0% | 3/2725 0% |
Mutation Distribution
Where ZUP1 is mutated · all tissues, split by cell line vs tissue
How many mutations in ZUP1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 330 mutations in ZUP1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|